Kukoamine A

SKU: orb1297612

Description

Kukoamine A is a multifunctional small molecule exhibiting anticancer, cytoprotective, antioxidant, and anti-inflammatory properties. It acts as a mixed inhibitor of trypanothione reductase (Ki = 1.8 µM), making it a compound of interest for research in parasitology, oncology, and oxidative stress studies in vitro.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 75288-96-9
• MW: 530.66
• Purity: 97.00% (May vary between batches)
• Formula: C₂₈H₄₂N₄O₆
• SMILES: Oc1ccc(CCC(=O)NCCCNCCCCNCCCNC(=O)CCc2ccc(O)c(O)c2)cc1O
• Target: NF-κB,DNA/RNA Synthesis,Lipoxygenase,Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.77 mM);DMSO:60 mg/mL (113.07 mM);H2O:100 mg/mL (188.44 mM)

Bioactivity

• Target IC50:
  Trypanothione reductase:1.8 microM(Ki)|LOX:9.5 microM
• In Vivo:
  Kukoamine A has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats.
• In Vitro:
  The four possible regioisomers of Kukoamine A, as well as a series of Kukoamine A analogs incorporating changes in either the SPM or the DHCA structural units, were evaluated for their antioxidant activity and their inhibitory activity on soybean lipoxygenase (LOX) and lipid peroxidation. The reducing properties of the compounds were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and found to be in the range 5-97.5%. Kukoamine A significantly inhibits LOX with IC50 9.5 microM. All tested analogs inhibited lipid peroxidation in the range of 11-100%.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AP-1, DNA Synthesis, DNASynthesis, Parasite, NF-κB, NFκB, NF-kB, NFkB, inhibit, Kukoamine A, LOX, Inhibitor, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

5318865