Kukoamine B mesylate

SKU: orb1980158

Description

Kukoamine B mesylate is a cationic alkaloid derived from dermatophytes, exhibiting antioxidant properties and inhibiting LPS uptake in Kupffer and RAW 264.7 cells. It serves as a useful research tool for investigating mechanisms of acute inflammation and diabetes in both in vitro and in vivo models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 1375179-86-4
• MW: 626.76
• Formula: C₂₉H₄₆N₄O₉S
• SMILES: O=C(NCCCNCCCCN(C(=O)CCC1=CC=C(O)C(O)=C1)CCCN)CCC2=CC=C(O)C(O)=C2.O=S(=O)(O)C
• Target: Antioxidant

Bioactivity

• In Vivo:
  A single dose of Kukoamine B Mesylate demonstrated good safety and tolerability in healthy subjects at dose levels ranging from 0.005 to 0.48 mg/kg. Kukoamine B Mesylate exhibits nonlinear pharmacokinetic characteristics, with a half-life of approximately 1.61 to 4.24 hours, primarily distributed in the plasma.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KukoamineBmesylate, Antioxidant

Compound Identifiers

PubChem CID

171360827