KU-60019

SKU: orb1686165

Description

KU-60019 is a potent and selective ATM kinase inhibitor with an IC50 of 6.3 nM. It is widely used in research to investigate DNA damage response pathways, both in cellular studies and in vivo models, to explore oncology and radiobiology.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 925701-46-8
• MW: 547.67
• Purity: 98.50% (May vary between batches)
• Formula: C₃₀H₃₃N₃O₅S
• SMILES: C[C@H]1CN(CC(=O)Nc2ccc3Sc4c(Cc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)C[C@@H](C)O1
• Target: ATM/ATR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.03 mM);DMSO:90 mg/mL (164.33 mM)

Bioactivity

• Target IC50:
  DNA-PKcs:1.7 μM|ATM:6.3 nM

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

925701-49-1, ATM, ATR, KU 60019, KU60019, KU-60019

Compound Identifiers

PubChem CID

15953870