KRpep-2d

• Catalog Number: orb1570915
• Category: Proteins
• Description: K-Ras inhibitor; Peptides.
• CAS Number: 2098181-84-9
• Purity: > 95% by hplc
• MW: 2560.02 Da
• Formula: C₁₀₉H₁₈₃N₄₃O₂₅S₂
• Structure: Ac-Arg-Arg-Arg-Arg-Cys*-Pro-Leu-Tyr-Ile-Ser-Tyr-Asp-Pro-Val-Cys*-Arg-Arg-Arg-Arg-NH2; disulfide bridge between cysteines 5 and 15
• Protein Sequence: Ac-RRRRC*PLYISYDPVC*RRRR-NH2
• Alternative names: 2098181-84-9, Ac-RRRRC*PLYISYDPVC*RRRR-NH2GT010, K
• Background: KRpep-2d is a potent K-Ras inhibitor, discovered after optimization of an initial hit obtained by phage display technology. KRpep-2d inhibits the enzyme activity of K-Ras(G12D) with an IC50 of 1.6 nM, and with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant in both cell-free enzyme and cell based assays. Mutated Ras proteins play important roles in cell differentiation, proliferation, and survival of various cancers, and K-Ras(G12D) is considered a very important target as K-Ras mutations underlie 86% of Ras-linked cancers, with 83% of K-Ras mutations being at the G12 residue. KRpep-2d can suppress ERK phosphorylation downstream of K-Ras(G12D) and reduce proliferation in A427 cancer cells.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.