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KRAS inhibitor-9

SKU: orb1298658

Description

KRAS inhibitor-9 (DUN09716) is a selective, mutation-targeting small molecule that binds KRAS with a Kd of 92 µM, inhibiting GTP-KRAS formation and downstream signaling. This activity leads to G2/M arrest and apoptosis in KRAS-mutant NSCLC cells, making it a valuable tool for in vitro studies of oncogenic KRAS biology and targeted therapy mechanisms.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number300809-71-6
MW292.81
Purity99.94% (May vary between batches)
FormulaC13H9ClN2S2
SMILESNc1ccc(Sc2nc3ccccc3s2)c(Cl)c1
TargetKras,Ras,Apoptosis
SolubilityDMSO:230 mg/mL (785.49 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

H358, H460, H2122, GTP-KRAS, Inhibitor, lung, mutant, inhibit, KRAS, KRAS inhibitor 9, KRAS inhibitor9, KRAS inhibitor-9, non-small, cytotoxicity, DUN09716, DUN-09716, DUN 09716, cells, cell, cancer, Apoptosis, Ras, proliferation

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
2 mg
$ 120.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 240.00
25 mg
$ 420.00
50 mg
$ 580.00
100 mg
$ 730.00
DispatchUsually dispatched within 5-10 working days
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