K-Ras(G12C) inhibitor 9

SKU: orb1300662

Description

K-Ras(G12C) inhibitor 9

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1469337-91-4
• MW: 513.78
• Purity: 98.31%
• Formula: C₁₆H₂₁ClIN₃O₄S
• SMILES: N(CC(=O)N1CCC(NS(C=C)(=O)=O)CC1)C2=C(OC)C=C(Cl)C(I)=C2
• Target: Raf,Ras
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (107.05 mM)

Bioactivity

• In Vitro:
  K-Ras(G12C) inhibitor 9 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ras, Inhibitor, inhibit, K Ras(G12C) inhibitor 9, K-Ras(G12C), KRas(G12C) inhibitor 9, K-Ras(G12C) inhibitor 9, K-Ras(G-12C) inhibitor 9

Compound Identifiers

PubChem CID

71761630