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KRAS inhibitor-18

SKU: orb1687259

Description

KRAS inhibitor-18 is a potent small molecule targeting KRAS G12C with an IC50 of 4.74 µM. It effectively inhibits p-ERK in cellular assays, such as in MIA PaCA-2 and A549 cell lines, supporting its research application in pancreatic, colorectal, and non-small cell lung cancer studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2230873-66-0
MW453.87
FormulaC20H15ClF3N3O2S
SMILESFC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(F)C=C(F)C(O)=C4
TargetRas,Kras,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information