KRAS inhibitor-14

SKU: orb1686806

Description

KRAS inhibitor-14 is a potent and selective KRAS G12C inhibitor with an IC50 of 0.249 µM. It demonstrates functional activity by inhibiting p-ERK in cellular assays, such as in MIA PaCA-2 cells, supporting its research application in pancreatic, colorectal, and non-small cell lung cancer models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2230873-78-4
• MW: 486.77
• Formula: C₂₀H₁₅Cl₃FN₃O₂S
• SMILES: FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C(Cl)=CC(O)=C4
• Target: Ras,Others,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135148879