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KRAS inhibitor-12

SKU: orb1687292

Description

KRAS inhibitor-12 is a potent and selective KRAS G12C inhibitor with an IC50 of 0.537 µM. It effectively suppresses p-ERK signaling in cellular models such as MIA PaCa-2 and A549 cells, supporting its research utility in pancreatic, colorectal, and non-small cell lung cancer studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2230874-00-5
MW452.33
FormulaC19H16Cl2FN5OS
SMILESFC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(N)=N4
TargetKras,Others,Ras

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information