K-Ras(G12C) inhibitor 12

SKU: orb1300663

Description

This small molecule is a selective, allosteric inhibitor of the oncogenic K-Ras(G12C) mutant protein. It is a valuable research tool for investigating Ras-driven cancers in both biochemical assays and cellular studies, supporting the development of targeted cancer therapies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1469337-95-8
• MW: 449.67
• Purity: 99.44% (May vary between batches)
• Formula: C₁₅H₁₇ClIN₃O₃
• SMILES: Oc1cc(Cl)c(I)cc1NCC(=O)N1CCN(CC1)C(=O)C=C
• Target: Raf,Ras,Apoptosis,Kras
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:26 mg/mL (57.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.22 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, K Ras(G12C) inhibitor 12, inhibit, K-Ras(G12C), KRas(G12C) inhibitor 12, K-Ras(G12C) inhibitor 12, K-Ras(G-12C) inhibitor 12, Inhibitor, Ras

Compound Identifiers

PubChem CID

73555129