KRAS G12C inhibitor 69

SKU: orb2945215

Description

KRAS G12C inhibitor 69 (Compound K09) is a potent small molecule inhibitor targeting the KRAS G12C mutant protein, demonstrating low nanomolar IC50 values in biochemical, cellular signaling (p-ERK), and proliferation assays in NCI-H358 and MIA PaCa-2 cell lines. This compound is a valuable research tool for investigating KRAS-driven oncogenesis and evaluating targeted therapies in vitro.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 588.02
• Formula: C₂₉H₂₉ClF₃N₅O₃
• SMILES: C=CC(=O)N1CCN(CC1)C2=NC(=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F)OC[C@@]56CCCN5C[C@@H](C6)F
• Target: Ras,Kras,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677015