Kobusin

SKU: orb3023822

Description

Kobusin is a bisepoxylignan isolated from Paeonia biondii Pamp. It acts as a dual modulator of chloride channels, activating CFTR and CaCC while inhibiting ANO1. This compound is a useful research tool for studying chloride transport in epithelial physiology and related diseases in cellular models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 36150-23-9
• MW: 370.4
• Purity: 99.79% (May vary between batches)
• Formula: C₂₁H₂₂O₆
• SMILES: O(C)C=1C=C([C@@H]2[C@@]3([C@@]([C@H](OC3)C=4C=C5C(=CC4)OCO5)(CO2)[H])[H])C=CC1OC
• Target: CFTR,Chloride channel
• Solubility: DMSO:80 mg/mL (215.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.91 mM)

Bioactivity

• In Vivo:
  Methods: HT-29 cells were treated with kobusin (0.1-1000 μM) to investigate the endogenous expression of CFTR and CaCCs in HT-29 cells and short-circuit current assays were performed to investigate the activation induced by kobusin and eudesmin. Results: Kobusin increased CFTR-mediated short-circuit currents in a dose-dependent manner. In the presence of 100 nM FSK, kobusin induced more robust CFTR-mediated short-circuit currents.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NOS, Kobusin, NFκB, NF-κB, NO Synthase, NF-kB, NFkB

Quick Database Links

Gene Symbol

CFTR,Chloride channel