Kobusin

SKU: orb2654368

Description

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells.

Key Properties

• CAS Number: 36150-23-9
• MW: 370.4
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂O₆
• Solubility: In Vitro: DMSO : 100 mg/mL (269.98 mM)

Bioactivity

• In Vivo:
  In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice.
• In Vitro:
  Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only