KN-92 phosphate

SKU: orb1302782

Description

KN-92 phosphate is an inactive control compound for the CaMKII inhibitor KN-93, which competitively inhibits calmodulin binding with a Ki of 370 nM. This tool compound is widely used in both in vitro and in vivo studies to investigate CaMKII signaling in neuroscience and cardiovascular research.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 1135280-28-2
• MW: 554.98
• Purity: 99.31% (May vary between batches)
• Formula: C₂₄H₂₈ClN₂O₇PS
• SMILES: OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)C\C=C\c1ccc(Cl)cc1
• Target: Autophagy,Others,CaMK
• Solubility: DMSO:55 mg/mL (99.1 mM)

Bioactivity

• Target IC50:
  CaMK II:370 nM(ki)
• In Vitro:
  KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

experimental, Inhibitor, inactive, KN-92, KN92 phosphate, KN92 Phosphate, KN-92 Phosphate, KN92-H3PO4, KN 92, KN 92 phosphate, KN 92 Phosphate, KN92, inhibit, derivative, control, CaMK, analog

Compound Identifiers

PubChem CID

16219540