KN-92 phosphate

SKU: orb1223423

Description

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

Key Properties

• CAS Number: 1135280-28-2
• MW: 554.98
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₈ClN₂O₇PS
• SMILES: OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)C\C=C\c1ccc(Cl)cc1
• Target: CaMK
• Solubility: H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth. The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21. Cell Viability Assay Cell line: Human hepatic stellate cells (LX-2). Concentration: 5-50 μM. Incubation time: 24 hours. Result: Ineffective in blocking cell growth.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CaMK