Klotho-derived peptide 1

SKU: orb3142357

Description

Klotho-derived peptide 1 (KP1 human) can inhibit the interaction between TGF-β and its receptor TGF-β receptor 2, suppressing the activation of Smad2/3 and mitogen-activated protein kinase (MAPK) induced by TGF-β. It shows anti-fibrotic and renal protective effects in mouse models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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Target	p38 MAPK,TGF-beta/Smad
Formula	C₁₄₉H₂₀₃N₃₉O₄₃

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

p38 MAPK,TGF-beta/Smad

Protocol Information

Protein Handling and Storage Guide

Protein Handling Guide

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Purity:	> 95% by HPLC
MW:	3228.48 Da
Structure:	H-Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly-OH

Purity:	99.97% (May vary between batches)
MW:	3228.44 (free base)