Klotho-derived Peptide 1 (56-87) (human) TFA

SKU: orb1980033

Description

KP1 (Klotho-derived peptide 1 (56-87)) is a human Klotho fragment that inhibits TGF-β signaling by binding to TGFBR1/TGFBR2. It reduces fibrotic markers like fibronectin and α-SMA in vitro and ameliorates kidney injury and fibrosis in murine UUO and ischemia-reperfusion models, demonstrating therapeutic research potential for renal fibrosis.

Research Area

Immunology & Inflammation, Stem Cell & Developmental Biology

Key Properties

• Target: TGF-beta/Smad
• MW: 3228.44 (free base)
• Purity: 99.97% (May vary between batches)
• Formula: C₁₄₉H₂₀₃N₃₉O₄₃.xCF₃COOH
• SMILES: [H]N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(O)=O)C(NCC(NCC(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)C)=O)C)=O)=O)=O)=O)C)=O)CC6=CNC7=C6C=CC=C7)=O)=O)CC8=CC=CC=C8)=O)=O)CC(O)=O)=O)=O)CC9=CC=CC=C9)=O)=O)=O)=O)CC%10=CC=CC=C%10.FC(F)(C(O)=O)F

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171361352