KL1333

SKU: orb1218606

Description

KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.

Key Properties

• CAS Number: 1800405-30-4
• MW: 240.26
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₂N₂O₂
• SMILES: CC(C)c1nc(-c(cccc2)c2C(C2=O)=O)c2[nH]1
• Target: NADPH
• Solubility: DMSO:245 mg/mL (1019.73 mM; Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NQO1 activator 1

Quick Database Links

Gene Symbol

NADPH