Ketohexokinase inhibitor 1

SKU: orb1308157

Description

This compound is a potent and selective inhibitor of ketohexokinase (KHK), exhibiting greater potency against the KHK-C isoform (IC50 = 8.4 nM) than the KHK-A isoform (IC50 = 66 nM). It is a valuable research tool for investigating fructose metabolism in models of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD) and diabetes, in both cellular and animal studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2102501-84-6
• MW: 356.34
• Purity: 99.66% (May vary between batches)
• Formula: C₁₆H₁₉F₃N₄O₂
• SMILES: C(C(O)=O)[C@@H]1[C@@]2([C@]1(CN(C2)C3=NC(=NC(C(F)(F)F)=C3)N4[C@@H](C)CC4)[H])[H]
• Target: Others
• Solubility: DMSO:125 mg/mL (350.79 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.23 mM)

Bioactivity

• Target IC50:
  KHK-C:8.4 nM|KHK-A:66 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KHK-A, KHK-C, Ketohexokinase inhibitor 1, PF 06835919, PF06835919, PF-06835919

Compound Identifiers

PubChem CID

129278694