GS-1291269

SKU: orb3174982

Description

GS-1291269 is a potent neutral ketohexokinase (KHK) inhibitor, exhibiting IC50 values of 0.38 nM for KHK-C and 2.1 nM for KHK-A. In a rat fructose challenge model, GS-1291269 effectively reduces fructose-1-phosphate (F1P) levels in the liver and kidneys. It is applicable in the study of renal diseases and metabolic dysfunction-associated steatotic liver disease (MASLD).

Key Properties

• CAS Number: 2845278-33-1
• MW: 474.45
• Formula: C₂₀H₁₉F₅N₄O₂S
• SMILES: FC1(F)C=2C(=C(N=C(N2)N3[C@@H](C(F)(F)F)CC3)C4=CC=C(C=C4)C5(N)CS(=O)(=O)C5)CC1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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