Kartogenin

SKU: orb1225007

Description

Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.

Key Properties

• CAS Number: 4727-31-5
• MW: 317.34
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₅NO₃
• SMILES: O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O
• Target: TGFBR
• Solubility: Ethanol: 18 mg/mL warmed (56.72 mM); DMSO: 63 mg/mL (198.52 mM)

Bioactivity

• In Vivo:
  Kartogenin (10 μM in 4μL of saline; i. a. on days 7 and 21) promotes cartilag erepair in collagenase VII-induced OA models in mice.
• In Vitro:
  Kartogenin (50-5000 nM; 2 weeks) induces the chondrogenetic differentiation of the BMSCs in a concentration-dependent manner. Kartogenin (100 nM; 72 h) induces chondrocyte nodule formation in primary hMSCs. Kartogenin (10 nM-10 μM; 72 h) increases chondrocyte-specific gene expression in hMSCs. Kartogenin (0.12-10 μM; 48 h) inhibits nitric oxide (NO) and glycosaminoglycan (GAG) release induced by cytokines in primary bovine articular chondrocytes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2(Biphenyl4yl)carbamoylbenzoic acid 4Phenylphthalanilic acid (8CI) KGN

Quick Database Links

Gene Symbol

TGFBR