Kanamycin sulfate

SKU: orb1225507

Description

Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic.(In Vitro):Kanamycin sulfate (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro.(In Vivo):Kanamycin sulfate (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice.Kanamycin sulfate (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice.

Key Properties

• CAS Number: 25389-94-0
• MW: 582.58
• Purity: >98% (HPLC)
• Formula: C₁₈H₃₈N₄O₁₅S
• SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
• Target: ribosome
• Solubility: Water: > 10 mg/mL

Bioactivity

• In Vivo:
  Kanamycin sulfate (2, 4 mg/kg; s. c. ; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice. Kanamycin sulfate (1.25, 5 mg/kg; s. c. ; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice. Animal model: Inbred strain normal mice (14-16 g; bovine tubercle bacilli (Ravenel strain) infected model). Dosage: 2, 4 mg/kg. Administration: Subcutaneous injection; once daily, 6 times a week for 3 weeks. Result: Exerted a marked effect to inhibit the multiplication of the tuberculosis In vivo, especially in the lung of mice. Animal model: Slc: ICR male mice (4-week-old; 18-24 g; K. pneumonia DT-S infection model (by the aerosol method)). Dosage: 1.25, 5 mg/kg. Administration: Subcutaneous administration; single (at 3 h after infection). Result: Suppressed the growth of K. pneumonia DT-S in lung, trachea, and blood in proportion to the dose administration. Resulted in 90% survival at 6 days after infection (negative control group: all died within 4 days), and cleared the K. pneumonia DT-S from lung, trachea, and blood of mice within 48 h (when dosage at 5 mg/kg).
• In Vitro:
  Kanamycin sulfate (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro. Cell Viability Assay Cell line: mycobacteria H37Rv, H2, H37RvR-PAS, Ravenel, Kirchbergand and BCG. Concentration: 0.1-100 μg/mL Incubation time: 2 weeks. Result: Showed good antibacterial activity to various strains of mycobacteria (H37Rv, H2, H37RvR-PAS, Ravenel, and BCG) with MICs were 1 μg/mL and 5 μg/mL for strain of Kirchbergand.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ophtalmokalixan

Quick Database Links

Gene Symbol

ribosome