kaempferide

SKU: orb1222178

Description

Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.

Key Properties

• CAS Number: 491-54-3
• MW: 300.27
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₂O₆
• SMILES: COc1ccc(cc1)c1c(c(=O)c2c(cc(cc2o1)O)O)O
• Target: ER
• Solubility: DMSO : 20 mg/mL 66.61 mM

Bioactivity

• In Vivo:
  Animal model: High-fat diet male C57BL/6J mice model. Dosage: 10 mg/kg. Administration: Supplemented in daily diet, once daily for16 weeks. Result: Reduced the weight, organ weight, and index of mice. Lowered the levels of glycolipids in mouse serum. Decreased the expression levels of inflammatory-related genes, including NF-κB, IL-6, ICAM-1, VCAM-1, and TNF-α. Animal model: Ischemia/Reperfusion (I/R) SD rat model. Dosage: 0.1 mg/kg, 0.3 mg/kg, 3 mg/kg. Administration: Injection, Single dose. Before the I/R injury induced by Coronary Artery Ligation (CAL) in SD rats. Result: Significantly improved heart function, reduced myocardial injury by reducing myocardial enzyme levels, and dose-dependently reduced the area of myocardial infarction in rats. Significantly decreased serum levels of TNF-α, IL-6, C-reactive protein (CRP), MDA, and ROS, while increasing serum levels of SOD. Downregulated the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and cleaved caspase-3, and upregulated the phosphorylation expression levels of phospho-Akt (p-Akt) and phospho-glycogen synthase kinase-3β (p-GSK-3β).
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• In Vitro:
  Western blot analysis. Cell line: HepG2. Concentration: 5 μM, 10 μM, 20 μM. Before treatment with OA (HY-N1446) (0.5 mM; 48 h) Incubation time: 48 h. Result: Lowered the expression of proteins related to fat production, including sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD-1). Reduced the expression of two adipogenic transcription factors, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer-binding protein β (C/EBPβ). Enhanced the expression of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Kaempferide

Quick Database Links

Gene Symbol

ER