K34C

SKU: orb1690093

Description

K34C is a selective integrin α5β1 inhibitor that induces apoptosis and suppresses survival, migration, and TGFβ-mediated invasion in U87MG glioblastoma cells. It also reduces cellular adhesion to fibronectin, making it a useful research tool for studying cancer cell biology and metastasis in vitro.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 939769-93-4
• MW: 447.53
• Purity: 99.66% (May vary between batches)
• Formula: C₂₆H₂₉N₃O₄
• SMILES: C([C@H](NC(=O)C1=C(C)C=CC=C1C)C(O)=O)C2=CC=C(OCCCNC3=CC=CC=N3)C=C2
• Target: Apoptosis,Integrin
• Solubility: DMSO:120 mg/mL (268.14 mM)

Bioactivity

• In Vitro:
  Methods: To evaluate the effect of K34C on apoptosis in U87MG glioblastoma cells, cells were treated with 20 μM K34C in combination with 1 μM Ellipticine for 24 or 48 hours. Apoptosis was assessed by measuring the sub-G1 cell population. Results: K34C combined with Ellipticine significantly induced apoptosis in U87MG cells, as evidenced by a marked increase in the sub-G1 population, suggesting that K34C enhances Ellipticine-induced apoptotic effects .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

K34c, K-34c

Compound Identifiers

PubChem CID

16663328