K34c hydrochloride

SKU: orb1741467

Description

K34c hydrochloride is a selective α5β1 integrin antagonist used in glioblastoma research. It has been applied in both in vitro cell adhesion assays and in vivo models to study tumor angiogenesis and invasion, providing a tool for investigating integrin-mediated pathways in cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2986315-25-5
• MW: 483.99
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₃₀ClN₃O₄
• SMILES: O=C(C1=C(C=CC=C1C)C)N[C@H](C(O)=O)CC2=CC=C(C=C2)OCCCNC3=CC=CC=N3.Cl
• Target: Integrin
• Solubility: DMSO:27.5 mg/mL (56.82 mM)

Bioactivity

• In Vitro:
  K34c (20 μM; 24 or 48 h) in combination with 1 μM Ellipticine induces significant apoptosis in U87MG cells. K34c (20 μM; 48 h) significantly decreases Temozolomide-induced senescence in cells transfected with control nontargeting siRNA, without significantly affecting the residual. K34c (20 μM; 24 h) alters the p53 pathway and senescence of cells transfected with siRNA specific for p53.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

K34c Hydrochloride, K34c hydrochloride(939769-93-4 Free base), Integrin α5β1

Compound Identifiers

PubChem CID

169553403