K02288

SKU: orb1307123

Description

K 02288 is a potent and selective small molecule inhibitor targeting ALK1, ALK2, ALK3, and ALK6 kinases. It is a valuable research tool for studying BMP and TGF-β signaling pathways in both cellular (in vitro) and animal (in vivo) models of bone formation, fibrosis, and cancer.

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1431985-92-0
• MW: 352.38
• Purity: 99.83% (May vary between batches)
• Formula: C₂₀H₂₀N₂O₄
• SMILES: COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1
• Target: TGF-beta/Smad,ALK
• Solubility: DMSO:50 mg/mL (141.89 mM);Ethanol:3.5 mg/mL (9.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.68 mM)

Bioactivity

• Target IC50:
  ALK3:34.4 nM|ALK1:1.8 nM|ALK6:6.4 nM|ALK2:1.1 nM
• In Vivo:
  K02288 dose-dependently inhibits Smad1/5/8 phosphorylation induced by BMP4 and BMP6 in C2C12 cells without affecting TGF-β-BMP signaling.
• In Vitro:
  In zebrafish embryos, K02288 induces dorsal phenotypes in a dose-dependent manner without affecting the formation of intersegmental vessels (ISV).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, K 02288, K02288, K-02288, ALK2, ALK3, ALK4, ALK1, ALK6, Transforming growth factor beta receptors, TGF-β Receptor, TGF-β/Smad, TGFβ, TGFb, TGF-b/Smad, TGFbeta/Smad, TGF-beta, TGFbeta, Smad

Compound Identifiers

PubChem CID

46173038