K02288

SKU: orb1226290

Description

K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4; also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM); specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos; inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis.

Key Properties

• CAS Number: 1431985-92-0
• MW: 352.3838
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₀N₂O₄
• SMILES: OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
• Target: TGFBR
• Solubility: DMSO: ≥ 58.6 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

K 02288 | K-02288

Quick Database Links

Gene Symbol

TGFBR