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K-Ras G12C-IN-12

SKU: orb1226221

Description

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells; relys on the mutant cysteine for binding and therefore do not affect the wild-type K-Ras.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1469337-95-8
MW449.6713
Purity>98% (HPLC)
FormulaC15H17ClIN3O3
SMILESC=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O
TargetRas
SolubilityDMSO: ≥ 48 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MDK-7958 | MDK7958 | MDK 7958 | K-Ras(G12C) inhibitor 12
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Protocol Information

Available Sizes

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200 mg
500 mg
2 mg
$ 130.00
5 mg
$ 200.00
10 mg
$ 320.00
25 mg
$ 520.00
50 mg
$ 770.00
100 mg
$ 1,110.00