JR14a

SKU: orb1218316

Description

JR14a is a potent antagonist of human complement C3a receptor.

Key Properties

• CAS Number: 2411440-41-8
• MW: 533.47
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₆Cl₂N₄O₃S
• SMILES: Cc1c(C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)sc(C(c(cc2)ccc2Cl)c(cc2)ccc2Cl)c1
• Target: C3a
• Solubility: DMSO : 90 mg/mL (168.71 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Male Wister rats (8 weeks, 250-300 g) were injected with BR103. Dosage: 10 mg/kg. Administration: p.o. 2 h prior to agonist challenge. Result: Inhibited C3aR-mediated inflammation. Animal model: Male Wister rats (8 weeks, 250-300 g). Dosage: 1 mg/kg for i. v. ; 10 mg/kg for oral (Pharmacokinetic Analysis). Administration: Intravenous administration and oral administration. Result: I. v. : t1/2 = 191 min, clearance = 4.4 mL/min/kg, AUC = 3795 ng h/mL. p.o. : Cmax = 88 ng/mL, Tmax = 300 min, AUC = 478 ng h/mL.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride

Quick Database Links

Gene Symbol

C3a