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JPS016

SKU: orb1982926

Description

JPS016 is a benzamide-based VHL-recruiting PROTAC that potently degrades HDAC1 and HDAC2. This degradation leads to widespread gene expression changes and induces apoptosis in cellular models like HCT116 cells, supporting its use in epigenetic and cancer research.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2669785-77-5
MW898.12
FormulaC48H63N7O8S
SMILESCc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)C(C)(C)C)cc1
TargetHDAC,PROTACs,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information