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JP-153

SKU: orb3028685

Description

JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1802937-26-3
MW365.379
FormulaC21H19NO5
SMILESO=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C=3C=CC=4C=CC=CC4C3N1
TargetFAK,Src

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • JP-153 [orb1568337]

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    1802937-26-3

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    C21H19NO5

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Protocol Information

JP-153 (orb3028685)

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