JNK-IN-8

SKU: orb1226337

Description

JNK-IN-8 is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively; exhibits exceptional selectivity based upon KinomeScan and enzymatic profiling; inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1410880-22-6
• MW: 507.6
• Purity: >98% (HPLC)
• Formula: C₂₉H₂₉N₇O₂
• SMILES: CN(C/C=C/C(NC1=CC=CC(C(NC2=CC=C(C(C)=C2)NC3=NC=CC(C4=CN=CC=C4)=N3)=O)=C1)=O)C
• Target: JNK
• Solubility: DMSO: ≥ 35 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNK-IN-8 | c-Jun N-terminal Kinase Inhibitor XVI

Quick Database Links

Gene Symbol

JNK