JNK-IN-7

SKU: orb1223319

Description

JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.(In Vitro):JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1408064-71-0
• MW: 493.56
• Purity: >98% (HPLC)
• Formula: C₂₈H₂₇N₇O₂
• SMILES: C(=O)(Nc1cccc(c1)C(=O)Nc1ccc(cc1)Nc1nccc(n1)c1cnccc1)/C=C/CN(C)C
• Target: JNK1| JNK2| JNK3
• Solubility: DMSO : 33.33 mg/mL. 67.53 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50 = 14.1 nM), YSK4 (IC50 = 4.8 nM), ERK3 (IC50 = 22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNK-IN-7 | JNK inhibitor | JNKIN7 | JNK IN 7

Quick Database Links

Gene Symbol

JNK1| JNK2| JNK3