JNJ-7706621

SKU: orb1225037

Description

A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM), and no activity for Plk1 or Wee1; arrests the cell cycle at the G2-M phase; shows significant antitumor activity in tumor xenograft model.

Key Properties

• CAS Number: 443797-96-4
• MW: 394.356
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₂F₂N₆O₃S
• SMILES: O=S(C1=CC=C(NC2=NN(C(C3=C(F)C=CC=C3F)=O)C(N)=N2)C=C1)(N)=O
• Target: CDK
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNJ7706621 | JNJ 7706621

Quick Database Links

Gene Symbol

CDK