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JNJ-63576253

SKU: orb1298247

Description

JNJ-63576253 is a clinical-stage small molecule androgen receptor (AR) antagonist active against both wild-type and F877L-mutant forms, targeting castration-resistant prostate cancer (mCRPC). It is utilized in preclinical research to investigate AR signaling and resistance mechanisms in relevant in vitro and in vivo models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2110428-64-1
MW538.97
Purity99.27% (May vary between batches)
FormulaC23H22ClF3N6O2S
SMILESCl.FC(F)(F)c1cc(cnc1C#N)N1C(=S)N(c2ccc(OC3CCNCC3)nc2)C2(CCC2)C1=O
TargetAndrogen Receptor
SolubilityH2O:insoluble;DMSO:200 mg/mL (371.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.28 mM)

Bioactivity

Target IC50
Androgen receptor:37nM
In Vitro
JNJ-63576253 inhibits the growth of VCaP cells,with an IC50 of 265nM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CRPC, castration, cancer, androgen, Androgen Receptor, AndrogenReceptor, Inhibitor, JNJ 63576253, inhibit, JNJ63576253, JNJ-63576253, mutant, LNCaP, prostate, resistant, wild-type, TRC 253, TRC253, TRC-253

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 160.00
25 mg
$ 290.00
50 mg
$ 440.00
100 mg
$ 630.00
DispatchUsually dispatched within 5-10 working days
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