JNJ-pan-AR

SKU: orb1738524

Description

JNJ-pan-AR is a methylated derivative of the potent oral androgen receptor (AR) antagonist JNJ-63576253 (TRC253). This novel pan-AR antagonist effectively inhibits both wild-type and mutant AR variants, such as F877L, blocking nuclear translocation and activation. It is a valuable research tool for studying prostate cancer resistance mechanisms in both cellular and animal models.

Key Properties

• CAS Number: 1332390-06-3
• MW: 515.55
• Formula: C₂₅H₂₄F₃N₅O₂S
• SMILES: O=C1C2(N(C(=S)N1C=3C=C(C(F)(F)F)C(C#N)=NC3)C4=CC=C(OC5CCN(C)CC5)C=C4)CCC2
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

86683482