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JNJ-?10198409

SKU: orb1217801

Description

JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent.

Images & Validation

Key Properties

CAS Number627518-40-5
MW325.34
Purity>98% (HPLC)
FormulaC18H16FN3O2
SMILESCOC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC
TargetPDGFR
SolubilityDMSO:83.33 mg/mL (256.13 mM; Need ultrasonic)

Bioactivity

In Vitro
JNJ-10198409 has potent antiproliferative activity in six of eight human tumor cell lines (IC50<0.033 μM) and is a potent inhibitor of the c-Abl kinase (IC50 = 22 nM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

JNJ-?10198409 (orb1217801)

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200 mg
500 mg
5 mg
$ 250.00
10 mg
$ 350.00
25 mg
$ 580.00
50 mg
$ 850.00
100 mg
$ 1,200.00