AS-8351

SKU: orb1223986

Description

AS-8351 (NSC 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409; competes with α-ketoglutarate (α-KG) for chelating iron/Fe(II) in certain epi-genetic enzymes, such as the JmjC-domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.(In Vitro):AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.

Key Properties

• CAS Number: 796-42-9
• MW: 291.31
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₃N₃O₂
• SMILES: OC1=CC=C2C=CC=CC2=C1/C=N/NC(C3=CC=NC=C3)=O
• Target: Histone Demethylase
• Solubility: DMSO: 29.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AS8351 | NSC 51355

Quick Database Links

Gene Symbol

Histone Demethylase