JMJD7-IN-1

SKU: orb1298375

Description

JMJD7-IN-1 is a potent small molecule inhibitor of JMJD7 with an IC50 of 6.62 µM. It demonstrates effective cellular activity against high JMJD7-expressing cells and serves as a valuable chemical probe for investigating JMJD7's role in enzymatic and cellular studies.

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 311316-96-8
• MW: 363.15
• Purity: 99.90% (May vary between batches)
• Formula: C₁₆H₈Cl₂N₂O₄
• SMILES: [O-][N+](=O)c1ccc(OC(=O)c2ccc(Cl)cc2Cl)c2ncccc12
• Target: Histone Demethylase
• Solubility: DMSO:3.64 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  JMJD7:6.62 μM
• In Vitro:
  JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM. JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively. JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Histone Demethylase, HistoneDemethylase, JMJD7, JMJD7 IN 1, JMJD7IN1, JMJD-7-IN-1, JMJD7-IN-1, inhibit, cancer, Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester

Compound Identifiers

PubChem CID

1514078