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JMJD7-IN-1

SKU: orb1218183

Description

JMJD7-IN-1 is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number311316-96-8
MW363.15
Purity>98% (HPLC)
FormulaC16H8Cl2N2O4
SMILESO=C(OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1)C3=CC=C(Cl)C=C3Cl
TargetJMJD7
SolubilityDMSO:10 mM

Bioactivity

In Vitro
JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM. JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM. JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester

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    311316-96-8

    363.15

    C16H8Cl2N2O4

    25 mg, 50 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 100 mg
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Protocol Information

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$ 90.00
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