JH-X-119-01

SKU: orb1298286

Description

JH-X-119-01 is a potent, selective, and irreversible small molecule inhibitor targeting IRAK-1 kinase. It is a valuable research tool for investigating TLR/IL-1R signaling pathways in immunological and inflammatory disease models, applicable in both cellular and in vivo studies.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2227368-54-7
• MW: 452.46
• Purity: 97.10% (May vary between batches)
• Formula: C₂₅H₂₀N₆O₃
• SMILES: C=CC(=O)Nc1cccc(c1)C(=O)Nc1ccc(NC(=O)c2cccc(n2)-c2cc[nH]n2)cc1
• Target: IRAK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.21 mM);DMSO:12 mg/mL (26.52 mM)

Bioactivity

• Target IC50:
  IRAK1:9 nM
• In Vitro:
  JH-X-119-01 exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Waldenstr?m, JH X 119 01, JHX11901, JH-X-119-01, inhibit, MYD88, Interleukin-1 receptor associated kinase, IL-1R associated kinase, IRAK, IRAK1, IRAK-1, macroglobulinemia, Inhibitor, Diffused Large B-cell Lymphoma

Compound Identifiers

PubChem CID

131704492