JH-X-119-01

SKU: orb1218408

Description

JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.

Key Properties

• CAS Number: 2227368-54-7
• MW: 452.46
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₀N₆O₃
• SMILES: O=C(C1=NC(C2=NNC=C2)=CC=C1)NC3=CC=C(NC(C4=CC=CC(NC(C=C)=O)=C4)=O)C=C3
• Target: IRAK
• Solubility: DMSO:Soluble

Bioactivity

• In Vivo:
  Animal model: C57BL/6 (20-22 g, male) mice. Dosage: 5 mg/kg and 10 mg/kg. Administration: Intraperitoneally injected; 5 days. Result: Protected mice from LPS (20 mg/kg)-induced sepsis. Survival at day 5 was 13.3% in control group where septic mice were treated by vehicle, while the values were 37.5% and 56.3% for 5 mg/kg and 10 mg/kg.
• In Vitro:
  Western blot analysis. Cell line: RAW 264.7 cells and THP-1 cells Concentration: 10 μM. Incubation time: 15 minutes. Result: Decreased LPS (100 ng/mL)-induced phosphorylation of IκBα and NF-κB-P65.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IRAK