JD-5037

SKU: orb1302847

Description

JD-5037 is a potent and selective CB1 receptor antagonist with an IC50 of 1.5 nM, designed for peripheral restriction. It is a valuable research tool for investigating metabolic disorders, such as obesity and fatty liver disease, in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1392116-14-1
• MW: 572.51
• Purity: 99.84% (May vary between batches)
• Formula: C₂₇H₂₇Cl₂N₅O₃S
• SMILES: CC(C)[C@H](\N=C(\NS(=O)(=O)c1ccc(Cl)cc1)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1)C(N)=O
• Target: Cannabinoid Receptor
• Solubility: DMSO:240 mg/mL (419.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.49 mM)

Bioactivity

• Target IC50:
  CB1 receptor:1.5 nM
• In Vivo:
  JD5037, when administered at a dosage of 3 mg/kg/day intraperitoneally (i.p.), effectively induces uniform reductions in body weight and mitigates high-fat diet (HFD)-induced hyperglycemia, hepatic injury, and steatosis in obese Magel2-null mice. Likewise, oral administration of JD5037 (3 mg/kg/day, p.o.) significantly diminishes tumor size and eliminates tumors in DEN-treated mice. Moreover, JD5037 reduces anandamide (AEA) levels in hepatocellular carcinoma (HCC) samples from mice.
• Animal Research:
  Mice: JD-5037 is formulated in vehicle (V; 1% Tween80, 4% DMSO, 95% Saline). Obese mice are treated chronically (28 d) with vehicle (V; 1% Tween80, 4% DMSO, 95% Saline), JD5037, or SLV319 at a dose of 3 mg/kg, i.p. Body weight and food intake are monitored daily. Mice are euthanized by cervical dislocation under anesthesia; the brain, hypothalamus, liver, and combined fat pads are removed, weighed, and snap-frozen, and trunk blood is collected for determining the endocrine and biochemical parameters

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, JD5037, JD-5037, JD 5037, CannabinoidReceptor, Cannabinoid Receptor, CB1R, CB

Compound Identifiers

PubChem CID

66553204