JAB-3068

SKU: orb1691167

Description

JAB-3068 (SHP2-IN-6) is a potent and selective SHP2 allosteric inhibitor used in cancer research. It demonstrates antitumor activity in preclinical models, supporting its investigation for breast, lung, and esophageal cancers in both in vitro and in vivo studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2169223-48-5
• MW: 476.54
• Purity: 99.78% (May vary between batches)
• Formula: C₂₂H₂₆F₂N₆O₂S
• SMILES: S(C1=C2C(N(C(C)=O)CC2(F)F)=CC=C1)C=3C(N)=NC(=CN3)N4CCC5(CC4)[C@H](N)COC5
• Target: Phosphatase
• Solubility: DMSO:100 mg/mL (209.85 mM)

Bioactivity

• In Vitro:
  JAB-3068 (SHP2-IN-6) is a potent PTPN11 and SHP2 inhibitor that blocks SHP2-mediated signaling, demonstrating potential anti-tumor activity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SHP2IN6, SHP-2-IN-6, SHP2-IN-6, SHP-2, SHP2 IN 6

Compound Identifiers

PubChem CID

132222602