IWP-O1

SKU: orb1301871

Description

IWP-O1 is a potent small molecule Porcn inhibitor with an EC50 of 80 pM. It effectively blocks Wnt signaling by inhibiting Dvl2/3 and LRP6 phosphorylation in vitro, making it a valuable tool for studying Wnt pathway biology in cancer and developmental research.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2074607-48-8
• MW: 432.48
• Purity: 99.98% (May vary between batches)
• Formula: C₂₆H₂₀N₆O
• SMILES: O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
• Target: Porcupine,Wnt/beta-catenin
• Solubility: DMSO:60 mg/mL (138.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM)

Bioactivity

• Target IC50:
  Porcn:80 pM (EC50, in L-Wnt-STF cells)
• In Vitro:
  IWP-O1functions by preventing the secretion of Wnt proteins. IWP-O1 effectively suppressed the phosphorylation of Dvl2/3 in HeLa cells. At the same time, the phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6). IWP-O1 suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, bcatenin, Inhibitor, inhibit, IWP O1, IWPO1, IWP-O1, IWP-O-1, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, Wnt, Porcupine, Porcn, βcatenin

Compound Identifiers

PubChem CID

134154594