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IWP-O1

SKU: orb1221044

Description

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM) effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

Images & Validation

Key Properties

CAS Number2074607-48-8
MW432.48
Purity>98% (HPLC)
FormulaC26H20N6O
SMILESO=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
TargetPorcupine
SolubilityDMSO: 100 mg/mL

Bioactivity

In Vitro
IWP-O1 (17) suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than the investigational drug LGK974.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • IWP-O1 [orb1301871]

    99.98% (May vary between batches)

    2074607-48-8

    432.48

    C26H20N6O

    5 mg, 10 mg, 25 mg, 2 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg
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Protocol Information

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 170.00
10 mg
$ 280.00
25 mg
$ 470.00
50 mg
$ 720.00
100 mg
$ 1,020.00