Ivosidenib

SKU: orb1303993

Description

Ivosidenib

Research Area

Metabolism Research

Key Properties

• CAS Number: 1448347-49-6
• MW: 582.96
• Purity: 99.98%
• Formula: C₂₈H₂₂ClF₃N₆O₃
• SMILES: Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N
• Target: Isocitrate Dehydrogenase (IDH),Dehydrogenase
• Solubility: 20% Cremophor EL:5.5 mg/mL (9.43 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:100 mg/mL (171.54 mM);DMSO:237 mg/mL (406.55 mM)

Bioactivity

• Target IC50:
  IDH1 (R132H):12 nM
• In Vitro:
  TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation.
• Cell Research:
  TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AG120, AG-120, AG 120, IDH, IDH1, Inhibitor, Ivosidenib, IsocitrateDehydrogenase(IDH), IsocitrateDehydrogenase, Isocitrate Dehydrogenase, Isocitrate Dehydrogenase (IDH), inhibit

Compound Identifiers

PubChem CID

71657455