Itraconazole

SKU: orb1223875

Description

A triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase; also has been shown to inhibit both the hedgehog signaling pathway and angiogenesis.Fungal Infection Approved(In Vitro):Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM).Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro.(In Vivo):Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 84625-61-6
• MW: 705.6334
• Purity: >98% (HPLC)
• Formula: C₃₅H₃₈Cl₂N₈O₄
• SMILES: O=C1N(C(CC)C)N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@@H]5O[C@@](CN6N=CN=C6)(C7=CC=C(Cl)C=C7Cl)OC5)C=C4)CC3)C=C2
• Target: Fungal
• Solubility: DMSO: ≥ 7.3 mg/mL

Bioactivity

• In Vivo:
  Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model. Animal model: Female outbred athymic nude mice (6-7-week-old) injected with Ptch+/ cells. Dosage: 75 mg/kg, 100 mg/kg. Administration: Oral gavage; twice per day; for 18 days. Result: Suppressed Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.
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• In Vitro:
  Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM). Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R51211

Quick Database Links

Gene Symbol

Fungal