ITK degrader 1

SKU: orb1982567

Description

ITK Degrader 1 is a potent and selective small molecule degrader of interleukin-2-inducible T-cell kinase (ITK), demonstrating in vivo activity (DC50=3.6 nM in mice) and effectively inhibiting T-cell receptor-stimulated IL-2 secretion in Jurkat cells (EC50=35.2 nM). This compound is a valuable chemical probe for researching ITK's role in T-cell signaling and immune responses, both in cellular and animal models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 943.02
• Formula: C₄₈H₅₇F₃N₁₀O₇
• Target: Others,Tyrosine Kinases,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others,Tyrosine Kinases,PROTACs