Isradipine

SKU: orb1310131

Description

Isradipine (PN 200-110) is a dihydropyridine L-type calcium channel blocker used as a research tool to study vascular smooth muscle contraction, hypertension, and cardiac function. It is applied in both in vitro receptor binding assays and in vivo models of cardiovascular disease to investigate calcium-mediated signaling pathways.

Research Area

Neuroscience

Key Properties

• CAS Number: 75695-93-1
• MW: 371.4
• Purity: >98%
• Formula: C₁₉H₂₁N₃O₅
• SMILES: C(OC(C)C)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C=2C=3C(C=CC2)=NON3
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Bioactivity

• Target IC50:
  Ca2+ channel:34±8 μM
• In Vivo:
  In vivo oxygen uptake (I50 = 31.1 mM) and growth incubation (I50 = 20.8 mM) assays showed that Isradipine was the most effective derivative. At micromolar concentrations, Isradipine inhibited oxygen consumption and growth incubation of the short-membrane form of Trypanosoma cruzi strain Tulahuen.
• In Vitro:
  In vivo oxygen uptake (I50 = 31.1 mM) and growth incubation (I50 = 20.8 mM) assays showed that Isradipine was the most effective derivative. At micromolar concentrations, Isradipine inhibited oxygen consumption and growth incubation of the short-membrane form of Trypanosoma cruzi strain Tulahuen.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

circulation, channel, dihydropyridine, Ca channels, Ca2+ channels, calcium, Calcium Channel, CalciumChannel, Autophagy, Inhibitor, inhibit, Isradipine, L-type, Parkinson's, neuroprotective, PN 200-110, peripheral, powerful, selective peripheral, vasodilator

Compound Identifiers

PubChem CID

3784