Isradipine

SKU: orb1310131

Description

Isradipine (PN 200-110) is a dihydropyridine L-type calcium channel blocker used as a research tool to study vascular smooth muscle contraction, hypertension, and cardiac function. It is applied in both in vitro receptor binding assays and in vivo models of cardiovascular disease to investigate calcium-mediated signaling pathways.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 75695-93-1
• MW: 371.39
• Purity: 99.95% (May vary between batches)
• Formula: C₁₉H₂₁N₃O₅
• SMILES: C(OC(C)C)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C=2C=3C(C=CC2)=NON3
• Target: Calcium Channel,Autophagy
• Solubility: Ethanol:7.4 mg/mL (19.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.39 mM);DMSO:250 mg/mL (673.15 mM)

Bioactivity

• Target IC50:
  Ca2+ channel:34±8 μM
• In Vivo:
  In vivo oxygen uptake (I50 = 31.1 mM) and growth incubation (I50 = 20.8 mM) assays showed that Isradipine was the most effective derivative. At micromolar concentrations, Isradipine inhibited oxygen consumption and growth incubation of the short-membrane form of Trypanosoma cruzi strain Tulahuen.
• In Vitro:
  In vivo oxygen uptake (I50 = 31.1 mM) and growth incubation (I50 = 20.8 mM) assays showed that Isradipine was the most effective derivative. At micromolar concentrations, Isradipine inhibited oxygen consumption and growth incubation of the short-membrane form of Trypanosoma cruzi strain Tulahuen.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

circulation, channel, dihydropyridine, Ca channels, Ca2+ channels, calcium, Calcium Channel, CalciumChannel, Autophagy, Inhibitor, inhibit, Isradipine, L-type, Parkinson's, neuroprotective, PN 200-110, peripheral, powerful, selective peripheral, vasodilator

Compound Identifiers

PubChem CID

3784